Investigation of the Effects of N-Acetylcysteine on Asprosin Hormone Activity and Liver Tissues in Rats with Experimentally-Induced Diabetes

Objective: To investigate the possible effect of N-acetylcysteine (NAC) treatment on rat diabetes-induced liver damage and immune reactivity asprosin hormone in liver. Material-Method: Twenty-eight Wistar albino male rats were used study. They separated into 4 groups as Control (n=7), Diabetes Diabetes+NAC NAC (n=7). The all dissected after treatment, tissues taken for pathological examination. Tissue sections stained with immunohistochemistry detecting immunoreactivity, hematoxylin-eosin picrosirius red staining performed to determine changes tissues. Result: In microscopical examination hematoxylin-eosin-stained normal histological hepatic seen groups. Pathological tissue from diabetic showed marked dissociation, fibrosis, degeneration, inflammation, necrosis, Kupffer cells activation, bile duct proliferation, congestion. A significant decrease these lesions was observed DM+NAC group. Immunohistochemical studies that immunoreactivity increased DM group a manner. Asprosin expression be significantly reduced comparison Conclusion: Our findings show administration reduces can reduce/eliminate negative effects diabetes tissue.